GW-501516 is a peroxisome Proliferator Activated Receptor delta (PPARδ) modulator substance that is also known as GW-1516 and GSK-516. It is a legal research drug developed by GlaxoSmithKline. However, GlaxoSmithKline has stopped its production and research due to independent studies that long term use of the said substance induces many kinds of organ cancers. Because of its potential, many laboratories are still conducting studies about it. It is popularly used among individuals who are seeking to augment their muscle building regimen. To this date, there are yet no clinical studies of this substance on humans. All previous studies were done on mice, rats and primates. But its promise and sworn testimonies by individual users online has outweighed the public warning issued by the World Anti-Doping Agency (WADA) about the reported serious toxicities of intake of this drug. The fact that GlaxoSmithKline stopped its production and research does not seem to bother men who want to boost their endurance.
As a PPARδ modulator, it acts by stimulating PPARδ, which is primarily located in the skin, brain and adipose tissues. When the PPARδ is activated or stimulated, it boosts the muscular endurance. Aside from stimulating the PPARδ, it also stimulates the adenosine monophosphate (AMP) activated protein kinase. When the AMP-activated protein kinase is stimulated, the body experiences an increase in cellular glucose uptake, oxidation of fat cells and energy levels. AMP-activated protein kinase is naturally stimulated by exercise. AMP-activated protein kinase can automatically detect metabolic stress of muscles and therefore increase cellular energy levels by stimulating catabolic processes such as oxidation of fat cells and usage of glucose for energy.
GW-501516 has been beneficial for obese men who usually experience metabolic anomalies. This substance is thus a potential treatment for obesity. For men seeking to augment their results during workout, this drug works by increasing endurance and cardiovascular health. This works by shortening recovery times between repetitions and maintaining high intensity. Unlike ordinary workouts, its usage prevents melting of muscle tissues for energy. Other drugs used to melt fat in conjunction with GW-1516 are T3 and clenbuterol, which are known catabolic drugs. As a result, although these drugs promote fat loss, they are known “muscle wasters.” It can also be added to the daily routine of trenbolone users to minimize the adverse side effects of trenbolone.
More men are being enticed to use GW-501516 because of the anecdotal statements of other men online. They have sworn that the regular intake of this substance produced positive results that they were after — fat reduction, endurance and libido boost and muscle hypertrophy. Unlike anabolic steroids that affect other tissues, the use of this substance has posed no reported side effects. Usage of anabolic steroids often comes with side effects such as acne, enhanced growth of body hair, high blood pressure, breast enlargement in men (Gynecomastia) and bouts of aggression and violence. Anabolic steroids are usually forms of testosterone or synthetic testosterone more commonly used to address body building concerns, delayed puberty and obesity.
There had been few studies conducted that showed that prolonged usage of GW-510516 has hastened formation of organ tumors and cancers. This is the alleged reason why GlaxoSmithKline has halted the production and further clinical studies on this drug. In another study published in October 2012, it has shown that the said substance has hastened liver fibrosis upon activation of PPARδ. Mice showed an increase of “various pro-fibrotic and pro-inflammatory genes” after being administered with CCL4 injections twice per week for 6 weeks straight. The research also tackled fibrotic livers of alcoholic patients and discovered that hepatic fibrotic tissues of the said patients.